近日，美国化学会志（JACS：Journal of the American Chemical Society）发表了美国美国罗切斯特大学医学中心Benjamin Miller博士研究小组的文章。该研究小组在实验室发现了一系列很有潜力治愈肌肉萎缩症的新化合物。

据研究发现，有毒RNA链是导致绝大多数肌肉萎缩症的根源，有毒RNA链通过吸附在MBNL1蛋白质上，阻止它在人体中应尽的功能，最终导致肌肉病症。Miller小组研究的小分子化合物能阻止这些有有毒RNA链，使MBNL1不受约束，从而达到治疗肌肉萎缩症的效果。

现在连科学家也不敢保证，自己的发明会不会在下一刻成其杯盘之中致命的“毒药”。三聚氰胺就是一个很有说服力的例子，人们怎么也不会想到，奶牛和母鸡会“产”出这样一种“化学物品”来。

三聚氰胺奶粉事件尘埃未定，又有鸡蛋检出三聚氰胺来。据说在食品和动物饲料中添加这种化学品已成“行业规则”，听听人们给它起的名字——“蛋白精”，就足见它的冠冕堂皇与名正言顺了。于是有人将谴责的矛头指向了技术的发明者，倘若没有它的问世，也便不会有这些罪恶。

这一看似偏激的指责，却道出了人们身处这个科技昌明时代的无奈。“蛋白精”之前，有“苏丹红”、“敌敌畏”、“孔雀石绿”，等等，这些本该造福于人类的工业技术发明，一旦被人类无所顾忌地穷其价值则就成了罪恶的推手。

科技这把双刃剑，“坏”的一面不仅仅在于其对自然环境的破坏，克隆人研究对人类伦理的挑战，那些看似寻常的、难言高端的技术发明，一旦失去了约束，则更为可怕，因为它操作简单又无需太高成本，当被浇上利益之油，远比我们忧心忡忡的克隆技术更胜于洪水猛兽。

英国学者施诺曾说，人类生活在两种文化之中，一个是人文的文化，一个是科学的文化。前者以“人”为中心价值，后者则以“技术”为中心追求。这两种文化的分裂，使科技变成了危险的东西。但是怎么融合，又是一个莫衷一是的命题。

有人说，如果那些发明三聚氰胺的科技工作者，能够尊重人、敬畏生命，如果“人文的文化”与“科技的文化”能够融合，还需要用生命和健康为国人普及三聚氰胺知识吗？但是事实上，这不是一个简单的道德假设。在现实中，我们显然很难要求一个科学家在发明三聚氰胺之前，要想到它会不会被用在食品和动物饲料中，因为他首先想的是三聚氰胺应用于工业会造福人类。

用道德和良知的底线去规矩科学研究也许符合伦理的要求，但以之约束科技的应用显然不符合现实的逻辑。科学家的发明如何被用上正途，不是科学家的事情，而是社会的事情。要保证科学成果不反过来伤害人类，除了道德层面的制约，更需要动用各种力量来监管、检测，甚至动用国家机器来惩处违反者。

三聚氰胺钻进鸡蛋，不是鸡蛋有缝，而是我们的制度有“缝”，才让不法商家下了蛆。类似的有害添加物的检测在我国一直是个空白，而美国早已明文规定三聚氰胺等不许作为饲料添加剂。从苏丹红到三聚氰胺，我们不能总是在问题出现之后，才“充分认识”到危险，才开始“管理”那个危险因子。

来源：张显峰的博客

绝大多数学化学的朋友都应该用SciFinder查阅过文献，相比CA光盘版，它的优势是可以直接链接全文，且支持更多种方式查询。看看下面的视频介绍吧！看SciFinder能为你做什么？

SciFinder promo

From Fairy Gloves to Nanocrystal

Ethanol, Fuel of the Future

Buckyball Powered Muscle Cars

Post-Katrina New Orleans

 前面科学堂发表了化学元素歌曲的各种版本，但歌曲的唱词太快，不利于大家掌握各种元素。下面这个视频，对元素周期表中的各个元素的性质进行了描述，并相关的简单实验，寓学于娱乐，让大家在10分钟内就能掌握118号化学元素。

在Web of Science数据库中还包含了两个化学数据库。这是专门为满足化学与药学研究人员的需求所设计的数据库。收集了全球核心化学期刊和发明专利的所有最新发现或改进的有机合成方法，提供最翔实的化学反应综述和详尽的实验细节，提供化合物的化学结构和相关性质，包括制备与合成方法。例如，我们要查找有关戊二醛的合成的文献，您可以这样操作：

1．访问Web of Science数据库并选择化学结构检索方式
请访问：www.isiknowledge.com, 进入ISI Web of Knowledge平台； 选择Web of Science数据库，(以下图示为WOK4.0版新界面)。

2．该页面显示就是戊二醛合成的相关文献

3. 该页面显示的就是引用了作者董绍俊院士的《化学修饰电极》一书的文章列表，这些文章涉及了书中理论的应用或者对书中理论的发展。

结论：通过 Web of Science 提供的独特的引文检索途径，您可以以一篇文章、一个作者、一个期刊、一篇会议文献或者一本书作为检索词,进行被引文献的检索，从而了解某一理论有没有得到进一步的证实？是否已经应用到了新的领域?某项研究的最新进展及其延伸如何等。

来源：Thomson Reuters

1、钢琴伴奏版

2、元素周期表闪烁版

3、教授实验室搞笑版

4、卡通版

5、天才小孩版

6、元素单质实物版

7、清晰字幕版

8、男女对唱版

说明：本文是哈佛化学与化学生物学学院G. M. Whitesides教授研究小组内部分发的论文写作方法，从中我们不但可以学到如何有效的写作论文，而且可以学到一个科研小组是如何协作完成论文的写作。

Whitesides Group: Writing a  Paper
George M. Whitesides
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA

1.What is a scientific paper?

A paper is an organized description of hypotheses, data and conclusions, intended to instruct the reader. Papers are a central part of research. If your research does not generate papers, it might just as well not have been done. “Interesting and unpublished” is equivalent to “non-existent.”
[科技论文是集假说、数据和结论为一体的概括性描述]
Realize that your objective in research is to formulate and test hypotheses, to draw conclusions from these tests, and to teach these conclusions to others. Your objective is not to “collect data.”
[研究的目的是为了形成并证实假说，得出结论，不是简单的数据收集。]
A paper is not just an archival device for storing a completed research program, it is also a structure for planning your research in progress. If you clearly understand the purpose and form of a paper, it can be immensely useful to you in organizing and conducting your research. A good outline for the paper is also a good plan for the research program. You should write and rewrite these plans/outlines throughout the course of the research. At the beginning, you will have mostly plan; at the end, mostly outline. The continuous effort to understand, analyze, summarize, and reformulate hypotheses on paper will be immensely more efficient for you than a process in which you collect data and only start to organize them when their collection is“complete.”
[论文并不仅是收集研究结果，也有助于形成进一步的研究工作的框架][好的文章提要也是研究工作的好计划，在研究的过程中，应该反复修改这些计划或提要。研究工作开始时，应有完善的计划；工作结束时，应充分的总结。]

2.Outlines

2.1 The reason for outlines.
I emphasize the central place of an outline in writing papers, preparing seminars, and planning research. I especially believe that for you, and for me, it is most efficient to write papers from outlines. An outline is a written plan of the organization of a paper, including the data on which it rests. You should, in fact, think of an outline as a carefully organized and presented set of data, with attendant objectives, hypotheses and conclusions, rather than an outline of text.
[按照提纲进行写作是最有效的方法][提纲是一篇论文的行文计划，应该包括论文所依靠的数据。提纲不仅仅是列出各段的内容， 而是按照目的， 假说， 结论来精心组织数据。]
An outline itself contains little text. If you and I can agree on the details of the outline (that is, on the data and organization), the supporting text can be assembled fairly easily. If we do not agree on the outline, any text is useless. Much of the time in writing a paper goes into the text; most of the thought goes into the organization of the data and into the analysis. It can be relatively efficient to go through several (even many) cycles of an outline before beginning to write text; writing many versions of the full text of a paper is slow.
[在我们就提纲达成一致以前，写正文是没有意义的][在动笔前，详细讨论几遍写作提纲会提高写作效率；写很多遍正文反倒很慢]
All the writing that I do - papers, reports, proposals (and, of course, slides for seminars)- I do from outlines. I urge you to learn how to use them as well.

2.2 How should you construct an outline?
The classical approach is to start with a blank piece of paper, and write down, in any order, all important ideas that occur to you concerning the paper. Ask yourself the obvious questions:“Why did I do this work?” “What does it mean?”“What hypothesis did I mean to test?”“What ones did I actually test?”“What were the results?”“Did the work yield a new method or compound? What?”“What measurements did I make?”“What compounds? How were they characterized?” Sketch possible equations, figures, and schemes. It is essential to try to get the major ideas written down. If you start the research to test one hypothesis, and decide, when you see what you have, that the data really seem to test some other hypothesis better, don’t worry. Write them both down, and pick the best combinations of hypotheses, objectives and data. Often the objectives of a paper when it is finished are different from those used to justify starting the work. Much of good science is opportunistic and revisionist.
[找一页空白的纸，以任何顺序，写下与这篇文章有关的所有重要观点][自问一些显而易见的问题][如果你的研究开始是为证实一个假设，然而当你发现你有的数据仿佛真的可以更好地验证其它的假设时，你也不必担心。把它们两者都写出来，去选择假设，目的和数据的最佳组合。]
When you have written down what you can, start with another piece of paper and try to organize the jumble of the first one. Sort all of your ideas into three major heaps (A-C).
[试着草拟一份提纲。将你的观点分成三大类]
A) Introduction
Why did I do the work? What were the central motivations and hypotheses?
[为什么我要做这件工作，主要的目的和假设是什么？]
B) Results and Discussion
What were the results? How were compounds made and characterized? What was measured?
[结果是什么？化合物是怎样合成与表征的？测试方法是什么？]
C) Conclusions
What does it all mean? What hypotheses were proved or disproved? What did I learn? Why does it make a difference?
[所有这一切意味着什么？证实或否定了什么假设？我学到了什么？结果为什么与众不同？]
Next, take each of these sections, and organize it on yet finer scale. Concentrate on organizing the data. Construct figures, tables, and schemes to present the data as clearly and compactly as possible. This process can be slow - I may sketch a figure 5-10 times in different ways, trying to decide how it is most clear (and looks best aesthetically).
[把每一部分再仔细组织。尤其是要集中整理数据。要尽可能把数据以清晰、紧凑的图表来展示]
Finally, put everything—outline of sections, tables, sketches of figures, equations - in good order.
[最后，把所有这些—内容的提纲、表格、草图、方程式，排好顺序。]
When you are satisfied that you have included all the data (or that you know what additional data you intend to collect), and have a plausible organization, give the outline to me. Simply indicate where missing data will go, how you think (hypothesize) they will look, and how you will interpret them if your hypothesis is correct. I will take this outline, add my opinions, suggest changes, and return it to you. It usually takes 4-5 repeated attempts (often with additional experiments) to agree on an outline. When we have agreed, the data are usually in (or close to) final form (that is, the tables, figures, etc., in the outline will be the tables, figures,…in the paper.)
[当你已经囊括了所有的数据（或者你明确知道你还需要收集哪些额外的数据），有了一个合理的构架，你对这些都感到满意时，将大纲交给我。简要地标明哪些地方还缺数据，你认为（或推测）这些数据大概是什么样。如果你的推测是正确的，你将如何去解释它。拿到你的大纲后，我将把我的观点，建议反馈给你。一般，我们需要四或五个来回才能达成一致（中间经常还需要补做一些实验）。在我们的意见一致后，所有的数据通常以最终（或接近最终的）形式确定下来（也就是说，在提纲中的表格，图表等最终将成为文章中的表格，图表）。]
You can then start writing, with some assurance that much of your prose will be used.
[然后，你就可以开始动笔写，注意你写的这些大多将用于正文。]
The key to efficient use of your and my time is that we start exchanging outlines and proposals as early in a project as possible. Do not, under any circumstances, wait until the collection of data is “complete” before starting to write an outline. No project is ever complete, and it saves enormous effort and much time to propose a plausible paper and outline as soon as you see the basic structure of a project. Even if we decide to do significant additional work before seriously organizing a paper, the effort of writing an outline will have helped to guide the research.
[合理使用我们的时间的关键是，我们应尽可能早地交换提纲和建议。在任何情况下，都不要等到你已经收集“全”了数据之后才开始动笔写提纲。研究是永无止境的。当你看到你的结果初具雏形时，就要立即开始准备构思文章和提纲，这将节省你很多的精力和时间。即便在认真组织成文前，我们已经决定补做重要的其他实验，试着写一个提纲也一定对研究有指导意义。]

2.3 The outline
What should an outline contain?

1.Title:

2.Authors:

3.Abstract: Do not write an abstract. That can be done when the paper is complete.
[不要着急写摘要，可以等文章写完后再写。]

4.Introduction:

The first paragraph or two should be written out completely. Pay particular attention to the opening sentence. Ideally, it should state concisely the objective of the work, and indicate why this objective is important.
[文章的第1或2段应该完全用来写引言]
In general, the Introduction should have these elements:
*The objectives of the work.
*The justification for these objectives: Why is the work important?
*Background: Who else has done what? How? What have we done previously?
*Guidance to the reader. What should the reader watch for in the paper? What are the interesting high points? What strategy did we use?
[引言应该包含以下几个要素：工作目的。对工作目的评价：该工作为什么很重要？工作背景：谁做了什么工作？做得怎么样？以前我们做了哪些工作？导读：读者应该注意该文章的哪些方面？有意义的要点有哪些？我们用到了哪些策略？]
*Summary conclusion. What should the reader expect as conclusion? In advanced versions of the outline, you should also include all the sections that will go in the Experimental section (at this point, just as paragraph subheadings).

5.Results and Discussion.
The results and discussion are usually combined. This section should be organized according to major topics. The separate parts should have subheadings in boldface to make this organization clear, and to help the reader scan through the final text to find the parts that interest him or her. The following list includes examples of the phrases that might plausibly serve as section headings:
[这一部分应根据主题来进行组织。分段应有黑体字的副标题，目的是使文章更有条理，能帮助读者清楚地通览全文，并找到他们感兴趣的内容。]
*Synthesis of Alkane Thiols
*Characterization of Monolayers
*Absolute Configuration of the Vicinal Diol Unit
*Hysteresis Correlates with Roughness of the Surface
*Dependence of the Rate Constant on Temperature
*The Rate of Self-Exchange Decreases with the Polarity of the Solvent
Try to make these section headings as specific and information-rich as possible. For example, the phrase “The Rate of Self-Exchange Decreases with The Polarity of The Solvent” is obviously longer than “Measurement of Rates,” but much more useful to the reader. In general, try to cover the major common points:
[尽可能使副标题具体并且内容丰富，尽量概括该段落的共同点]
*Synthesis of starting materials
*Characterization of products
*Methods of characterization
*Methods of measurement
*Results (rate constants, contact angles, whatever)
In the outline, do not write any significant amount of text, but get all the data in their proper place: any text should simply indicate what will go in that section.
*Section Headings
*Figures (with captions)
*Schemes (with captions and footnotes)
*Equations
*Tables (correctly formatted)
[在提纲中，不要罗列大量的正文内容，而是要给出数据应放的合适位置：任何正文应该简明地指出那段中包括了什么数据。]
Remember to think of a paper as a collection of experimental results, summarized as clearly and economically as possible in figures, tables, equations, and schemes. The text in the paper serves just to explain the data, and is secondary. The more information that can be compressed into tables, equations, etc., the shorter and more readable the paper will be.
[把文章看作实验结果的集合，并尽可能清晰和简洁地总结在图表，表格，方程和示意图中。论文中的正文是为解释数据服务的，因而它是次要的。可以被压缩进表格，方程等的信息越多，文章越短，越易读。]

6.Conclusion.
In the outline, summarize the conclusions of the paper as a list of short phrases or sentences. Do not repeat what is in the Results section, unless special emphasis is needed. The Conclusions section should be just that, and not a summary. It should add a new, higher level of analysis, and should indicate explicitly the significance of the work.
[在提纲里，总结论文中的结论应是由一些简短的短语或句子组成][结论不仅仅只是一个总结。它应该增加新的，更高层次的分析，并且应该明确地指出这项工作的意义。]

7. Experimental.
Include, in the correct order to correspond to the order in the Results section, all of the paragraph subheadings of the Experimental section.

2.4 In summary:[总结：]
* Start writing possible outlines for papers early in a project. Do not wait until the “end”. The end may never come.
[在一个项目开始时，就应该着手去写可能的论文提纲，而不要等到论文结束的时候。研究可能永远没有结尾可言。]
* Organize the outline and the paper around easily assimilated data - tables, equations, figures, schemes - rather than around text.
[整理提纲和论文要围绕易于接受的数据—表格，方程式，图表，示意图，而不是围绕正文。]
* Organize in order of importance, not in chronological order. An important detail in writing paper concerns the weight to be given to topics. Neophytes often organize a paper in terms of chronology: that is, they recount their experimental program, starting with their cherished initial failures and leading up to a climactic successful finale. This approach is completely wrong. Start with the most important results, and put the secondary results later, if at all. The reader usually does not care how you arrived at your big results, only what they are. Shorter papers are easier to read than longer ones.
[不是按照时间顺序, 而应按重要性来整理。应该从最重要的结果写起，然后是较重要的结果。读者们通常不关心你是怎么得到的结果，而只关心结果是什么]

3. Some Points of English Style

[英文文体上的一些要点：]
1) Do not use nouns as adjectives:
2) The word “this” must always be followed by a noun, so that its reference is explicit
3) Describe experimental results uniformly in the past tense.
[描述实验结果一律要用过去时态。]
4) Use the active voice whenever possible.
5) Complete all comparisons.
6) Type all papers double-spaced (not single-or one-and-a-half spaced), and leave 1 space after colons, commas, and after periods at the end of sentences. Leave generous margins. (generally, 1.25” on both sides & top & bottom).
Assume that we will write all papers using the style of the American Chemical Society. You can get a good idea of this style from three sources:
1) The Journal. Simply look at articles in the journals and copy the organization you see there.
2) Previous papers from the group. By looking at previous papers, you can see exactly how a paper should “look”. If what you wrote looks different, it probably is not what we want.
3) The ACS Style Guide: A Manual for Authors and Editors. (Janet S. Dodd, Editor Washington, D.C. USA 1997) . Useful detail, especially the section on references.
I also suggest you read Strunk and White, The Elements of Style (Longman: New York, 2000, 4th edition) to get a sense for English usage. Two excellent books on the design of graphs and figures are: “The Visual Display of Quantitative Information” by Edward R. Tufte, Graphics Press (1983)— and “Envisioning Information” also by Edward R. Tufte, Graphics Press (1990).

来源：麦立强的博客